Mycophenolic Acid and Immune Suppression

//Mycophenolic Acid and Immune Suppression

Mycophenolic Acid and Immune Suppression

I wrote here on how to identify mold-related biotoxin illnesses. Symptoms can be quite diverse, but can include chronic sinusitis, frequent bloody noses, fungal overgrowth, shortness of breath, fatigue, and chemical sensitivity, just to name a few.

If you know you’ve been exposed to a water-damaged building, or suspect you might have been, insurance-covered testing generally involves three white blood cell markers: TGFb1, complement c3a and c4a (though LabCorp. They’re the only lab that does these.)

But there is one mycotoxin in particular that might cause these markers to turn up a false negative.

Mycophenolic Acid Induces Immune Suppression

Mycophenolic acid, produced from the penicillium fungus, is actually such a potent immunosuppressant that it is often used to prevent rejection in renal transplant patients. 

It inhibits both B and T cells, and because of that it can increase the risk of opportunistic infections too.

What this means for those suffering from biotoxin illness: the white blood cell markers typically used to identify mold toxicity might be artificially suppressed. It can suppress TGFb1, and and since complement elevation is one of the things watched for in transplants, presumably it can suppress those as well.

The Upshot

If you have symptoms of mold toxicity, perhaps genetic susceptibility (as shown by an HLA DR test) and/or a known mold exposure, but the biotoxin markers aren’t showing it, consider running a mycotoxin urine test to determine if mycophenolic acid might be the culprit. It’s an out-of-pocket test, but it might explain the discrepancy.



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By |2020-01-31T10:10:38-07:00January 31st, 2020|Categories: Articles|0 Comments

About the Author:

Dr. Lauren Deville is board-certified to practice medicine in the State of Arizona. She received her NMD from Southwest College of Naturopathic Medicine in Tempe, AZ, and she holds a BS in Biochemistry and Molecular Biophysics from the University of Arizona, with minors in Spanish and Creative Writing. She also writes fiction under a pen name in her spare time. Visit her author website at


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