Depression and Your Hypothalamus

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Depression and Your Hypothalamus

Physiology 101:

Your thalamus is like the manager of your brain.  All the signals from your body route through your thalamus to your cerebral cortex, where you actually do your thinking, and all of your thoughts route through your thalamus before affecting other parts of your body.

Your hypothalamus sits right below the thalamus (hypo means below or beneath, just like hypothyroid means your thyroid is underactive).  The hypothalamus is responsible for the body’s homeostasis, or balance with the outside world.  It regulates a number of functions, including body temperature, thirst (and thus, fluid balance and blood pressure), hunger, sleep, sex drive, bonding, “fight or flight” responses to threats, and mood.

The hypothalamus is one of several structures included in what is considered the brain’s limbic system, considered to be the seat of emotions in the brain.  Depression, whether organic or caused by an outside event, is associated with an overactive hypothalamus.

Symptoms of an Overactive Hypothalamus

Dr Daniel Amen (“Change Your Brain, Change Your Life”) calls this an overactive “deep limbic system”, which is shown on SPECT studies to correlate well with clinical depression.  You can pretty well guess what will be affected when the hypothalamus is overactive, based on its actions listed above:

  • moodiness and irritability
  • negative thinking, hopelessness, and negative interpretation of events
  • low motivation (usually due to apathy – “What does it matter what I do anyway?  Nothing ever works out.”)
  • appetite and sleep dysregulation
  • abnormally high or low sexual interest
  • tendency to isolate socially, and a hindered ability to form relational bonds

If you think of depression as an overactive hypothalamus, then it makes sense that it is most frequently associated with decreased amounts of the neurotransmitters serotonin and epinephrine – the more active the structure, the more of the messengers it’s likely to burn through.

Techniques and Prescriptions

I wrote about lifestyle techniques to help cool an overactive hypothalamus a few weeks ago, and I definitely recommend you try these before taking any meds, or in addition to medication, if you are already taking it.

Very often, people have an overactive hypothalamus due to repetitive negative thoughts.  It’s important to remember that you are in control of your thoughts.  You are capable of taking a step back, listening to what you are thinking, deciding whether or not those thoughts are helpful or harmful to you, and rejecting those thoughts that are harmful.  It will definitely be a battle at first, but will get easier over time.  I often share a biblical approach to this process with my patients, and I’ve shared it with you here.

There are also some natural, over-the-counter approaches to minimize depressive symptoms as well, based on the principle that depression is correlated with low serotonin (due to an overactive hypothalamus).  These are the biochemical precursors for serotonin.

  • L-Tryptophan: this is an amino acid, most famously present in high concentration in turkey meat.  This becomes 5HTP, which becomes serotonin, which becomes melatonin (the sleep hormone) – and that’s why the joke is that everybody goes to sleep after Thanksgiving dinner!  I like to suggest this as the first supplement to try, because your body gets to decide what it wants to make with it (as long as you’ve got enough of the basic nutrients to facilitate the process).  Recommended dose: 1000 mg before bedtime.
  • 5HTP: I’d recommend caution with this one simply because it’s a “committed pathway” to serotonin.  Your body no longer gets to decide whether it needs more serotonin or not, and it is possible to overdose of serotonin.  Use this only under the guidance of a health care practitioner.
  • St John’s Wort: be careful with this one too.  It increases the concentration of many pharmaceuticals in the bloodstream, so I would avoid it if you are already taking prescription or over the counter medications.  It also directly raises serotonin in the body, so again, there’s a possibility of overdose.  Finally, it can cause sun sensitivity.

Since some depression is associated with low epinephrine as well or instead of low serotonin, some people might do better with those biochemical precursors instead.  These patients might have issues with energy and focus in addition to the symptoms of a hyperactive hypothalamus.

  • DL-Phenylalanine: this is also an amino acid found in most animal meats.  This converts to tyrosine, which then goes on to become dopamine, epinephrine, and norepinephrine in the body.  You want to make sure you take this one on an empty stomach, and the dose is around 1500 mg per day in divided doses.
  • Tyrosine: the next step down the pathway, this one can be rather stimulating so make sure you don’t take it after 4 pm.  The recommended dose is around 1000 mg daily.

For resistant cases, I test for neurotransmitters through a company called NeuroScience.  This tells me which neurotransmitters are high, which are low, and which precursors and cofactors an individual needs in order to help restore balance.  Unfortunately the test is not covered by insurance, but I have found it to be very helpful for many of my more challenging patients.

If you have the ability to see a naturopathic doctor to coordinate your care, that is always best. However, if you do not live near one, here are some good products you might try. Bonus: FREE Shipping! 

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By | 2017-05-30T07:37:32+00:00 August 2nd, 2013|Categories: Articles, Mental Health|Tags: , |6 Comments

About the Author:

Dr. Lauren Deville is board-certified to practice medicine in the State of Arizona. She received her NMD from Southwest College of Naturopathic Medicine in Tempe, AZ, and she holds a BS in Biochemistry and Molecular Biophysics from the University of Arizona, with minors in Spanish and Creative Writing. She also writes fiction under a pen name in her spare time. Visit her author website at www.authorcagray.com.

6 Comments

  1. […] support often helps people get un-stuck.  As mentioned in last week’s article on depression, L-tryptophan is usually my go-to for stabilizing serotonin before moving on to 5-HTP (which is a […]

  2. […] Are you depressed? […]

  3. […] creating most of your neurotransmitters. For this reason, low folic acid can result in persistent depression, anxiety, and behavioral […]

  4. […] support often helps people get un-stuck.  As mentioned in last week’s article on depression, L-tryptophan is usually my go-to for stabilizing serotonin before moving on to 5-HTP (which is a […]

  5. […] at the synaptic cleft (the junction between neurons where the receptors are)—and, of course, serotonin is the “happy” neurotransmitter. It also increases the activity of the enzyme tryptophan […]

  6. […] as a reminder, serotonin is the neurotransmitter, or signaling molecule in the brain, most associated with a positive and […]

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